A Case Control Study of Metabolic Syndrome in Psoriasis Vulgaris Patients at Tertiary Care Institute


Rupinder Kaur
Anil Gugle
Rahul Kote
Vikrant Jadhav


Background: Psoriasis is a chronic, disfiguring, inflammatory and proliferative condition of skin influenced by both genetic and environmental factors. The prevalence of psoriasis vary from 0.1% to 3% in different population1. The pathogenesis of psoriasis is interplay of various inflammatory cytokines and chemokines which play an important role in the pathogenesis of various other systemic diseases. Psoriasis has been reported to be associated with metabolic syndrome which increases the risk of Coronary Artery Disease. Aim: To study the prevalence of metabolic syndrome among patients of psoriasis vulgaris. Setting and Study Design: This is a case-control study and was conducted at the out-patient clinic of Department of Dermatology, Venereology and Leprology of a tertiary care centre. Materials and Methods: Study was approved by the Institutional ethical committee. The patients were included in two study groups. 50 patients diagnosed with psoriasis vulgaris were included as cases. Fifty age and sex matched controls were included in the control group. The detailed demographic history, duration of disease, family history and personal history was taken. Patients were assessed for severity of psoriasis using PASI score and blood sample collected was analyzed for fasting blood sugar levels and serum lipid profile. The data collected was evaluated using Chi Square test and unpaired t test. Results: Total 50 patients were included as cases and controls respectively out of which 11 (22%) were females and 39 (78%) were males. The mean age of cases and controls was 45.85 and 46.04 respectively. The mean duration of psoriasis in cases was 78.86 months. The mean PASI score was the prevalence of Metabolic Syndrome in psoriasis vulgaris was 46% in our study. Conclusion: Metabolic syndrome is a significant morbidity which predisposes the patients for Coronary Artery Disease. The patients of psoriasis vulgaris should be routinely screened for hypetension, Type II diabetes mellitus and dyslipidemias.


How to Cite
Kaur, R., Gugle, A., Kote, R., & Jadhav, V. (2016). A Case Control Study of Metabolic Syndrome in Psoriasis Vulgaris Patients at Tertiary Care Institute. MVP Journal of Medical Sciences. Retrieved from https://mvpjms.org/index.php/mvpjms/article/view/226


  1. Pavithran K, Karunakaran M, Aparna P, Ragunatha S. Psoriasis. In: Valia RG, Valia AR, editors. Disorders of keratinization. IADVL textbook of Dermatology. 3rd ed. Reprint. Bhalani Publishing House; 2012. p. 1021–56.
  2. Griffiths CEM, Barker JNWN. Psoriasis. In: Tony B, Stephen B, Neil C, Christopher G, editors. Rook’s Textbook of Dermatology. 8th ed. Wiley-Blackwell; 2010. p. 20.1–20.54.
  3. Eckel RH. The metabolic syndrome. In: Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J, editors. Harrison’s principles of internal medicine. 17th ed. Mc Graw Hill Publications; 2008. P. 1509–14.
  4. Madanagobalane S, Anandan S. Prevalence of metabolic syndrome in south Indian patients with psoriasis vulgaris and the relation between disease severity and metabolic syndrome: A hospital-based case-control study. Indian J Dermatol. 2012; 57:353–7.
  5. Nisa N, Qazi MA. Prevalence of metabolic syndrome in patients with psoriasis. Indian J Dermatol Venereol Leprol. 2010; 76:662–5.
  6. Belliappa PR, Umashankar N. Psoriasis uncovered-comorbid conditions with special reference to metabolic syndrome. Our Dermatol Online. 2014; 5(1):14–7.
  7. Love TJ, Qureshi AA, Karlson EW, Gelfand JM, Choi HK. Prevalence of the metabolic syndrome in psoriasis: Results from the national health and nutrition examination survey, 2003-2006. Arch Dermatol. 2011; 147:419–24.
  8. Armstrong AW, Harskamp CT, Armstrong EJ. Psoriasis and metabolic syndrome: A systematic review and meta-analysis of observational studies. J Am Acad Dermatol. 2012; 68(4):654–62.
  9. Cohen AD, Gilutz H, Henkin Y, Zahger D, Shapiro J, Bonneh DY, Vardy DA. Psoriasis and the Metabolic Syndrome. Acta Derm Venereol. 2007; 87:506–9.
  10. Dreiher J, Weitzman D, Davidovici B, Shapiro J, Cohen AD. Psoriasis and dyslipidemia: A population based study. Acta Derm Venerol. 2008; 88:561–5.
  11. Khunger N, Gupta D, Ramesh V. Is psoriasis a new cutaneous marker for metabolic syndrome? A study in Indian patients. Indian J Dermatol. 2013; 58:313–4.

Most read articles by the same author(s)