Hyperbasophilic Variant of Acute Promyelocytic Leukemia


Preeti Bajaj
Rajyaguru Devangana
B. S. Shah
Amrinder Kaur


Acute Promyelocytic Leukemia (APL) is an extremely rare variant of acute myeloid leukemia. APL constitutes around 10-15 % of acute myeloid leukemia in adults. It is commonly diagnosed around 40 years age. Molecular/genetic studies exhibit chromosomal translocation between chromosome 15 and chromosome 17-t(15;17)(q22;q21) and PML-RARa rearrangement. Four variants of APL have been identified: The classic form M3 hypergranular variant, the microgranular variant, the hyperbasophilic form and zinc-finger form-M3r, identified by a different chromosomal translocation, between chromosome 11 and chromosome 17:t(11,17) (q23, q11-12).


How to Cite
Bajaj, P., Devangana, R., Shah, B. S., & Kaur, A. (2016). Hyperbasophilic Variant of Acute Promyelocytic Leukemia. MVP Journal of Medical Sciences. Retrieved from https://mvpjms.org/index.php/mvpjms/article/view/235


  1. References 1. Diana C, Vladareanu, et al. Acute promyelocytic leukemia microgranular variant- A clinical and therapeutical approach. Maedica- A Journal of Clinical Medicine. 2007; 2(4):327-331.
  2. Haslindawani WM, Haslina, et al. A case of hyperbasophilic form of acute promyelocytic leukemia. Malaysian Journal of Medical Sciences. 2008 Jan; Supplement:168.
  3. Soignet S, Maslak P. Acute promyelocytic leukemia. Wintrobe’s Clinical Hematology. 12th ed. USA: Lipincot Williams and Wilkins, Wolter- Kluwer Business; 2009. p. 1938– 55.
  4. Elizabeth J, Amita R, Mamta S, et al. An uncommon morphological variant of acute promyelocytic leukemia. American Journal of Hematology. 2011; 87(3):294. Available from: http://wileyonlinelibrary.com/cgi-bin/jhome/35105
  5. Mohamed M, Dun K, Grabek J. A typical features in a patient with acute promyelocytic leukemia: A potential diagnostic pitfall. BMJ Case Rep. 2013. DOI: 101136/bcr-2013- 200152.
  6. Ibrahim FA, Yassin MA, El-Ayoubi HR, Alhiji IA, Albinali AS, Almansour SM, Qafoud FM. Clinico-pathological profile of acute promyelocytic leukaemia at Al-Amal Oncology-Haematology Centre, Qatar. East Mediterr Health J. 2010 Sep; 16(9):958–65. PubMed PMID: 21218723.

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