Comparison Between Propofol and Etomidate in General Anaesthesia as Induction Agents at a Tertiary Care Centre


Alka Rajesh Koshire
Amala Anirudha Godse
Sarita Phulkar
Hemant Pawar


Aims: To compare hemodynamic changes occurring due to Propofol and Etomidate during general anesthesia as induction agents at a Tertiary Care Centre. Materials and Methods: 68 Adult ASA1 and ASA 2 Patients undergoing elective surgeries under gender anaesthesia in the department of Anaesthesia, Medical college and tertiary health care Centre after considering and satisfying the inclusion and exclusion criteria were selected and divided in two equal groups. They were given Propofol (2mg/kg) and Etomidate (0.3mg/kg) and hemodynamics were compared. Results: Etomidate was having more stable hemodynamic conditions as compared to Propofol induced anaesthesia. There was significant reduction in heart rate and blood pressure leading to hypotension in propofol group while etomidate group had stable hemodynamics. Conclusion: This study concludes that etomidate is a better agent for induction than propofol in view of hemodynamic stability.


How to Cite
Koshire, A. R., Godse, A. A. ., Phulkar, S. ., & Pawar, H. . (2022). Comparison Between Propofol and Etomidate in General Anaesthesia as Induction Agents at a Tertiary Care Centre. MVP Journal of Medical Sciences, 179–182.


  1. Stone JG, Foex P, Sear JW, Johnson LL, Khambatta HJ, Triner L. Risk of myocardial ischaemia during anaesthesia in treated and untreated hypertensive patients. British Journal of Anaesthesia. 1988; 61:675–9. PMid:3207540 DOI:
  2. Riznyk L, Fijalkowska M, Przesmycki K. Effects of thiopental and propofol on heart rate variability during fentanyl-based induction of general anesthesia. Pharmacological Reports. 2005; 57:128–34.
  3. Basu S, Mutschler DK, Larsson AO, Kiiski R, Nordgren A, Eriksson MB. Propofol (Diprivan-EDTA) counteracts oxidative injury and deterioration of the arterial oxygen tension during experimental septic shock. Resuscitation. 2001; 50:341–8. DOI:
  4. Kelicen P, Ismailoglu UB, Erdemli O, Sahin-Erdemli I. The effect of propofol and thiopentone on impairment by reactive oxygen species of endothelium-dependent relaxation in rat aortic rings. European Journal of Anaesthesiology. 1997; 14:310–5. PMid:9202920 DOI:
  5. Hiller SC, Mazurek MS. Monitored anesthesia care. In: Barash PG, Cullen BF, Stoelting RK, editors. Clinical Anesthesia. 5th ed. Philadelphia: Lippincott Williams and Wilkins; 2006. p. 1246–61.
  6. Reves JG, Glass P, Lubarsky DA, McEvoy MD, MartinezRuiz R. Intravenous anesthesia. In: Miller RD, editor. Anesthesia. 7th ed. New York: Churchill Livingstone; 2010. p. 719–58. DOI:
  7. Morel J, Salard M, Castelain C, et al. Haemodynamic con- sequences of etomidate administration in elective cardiac surgery: a randomized double-blinded study. British Journal of Anaesthesia. 2011; 107:503–9. PMid:21685487 DOI:
  8. Sarkar M, Laussen PC, Zurakowski D, Shukla A, Kussman B, Odegard KC. Hemodynamic responses to etomidate on induction of anesthesia in pediatric patients. Anesthesia and Analgesia. 2005; 101:645–50. PMid:16115968 DOI:
  9. Eames WO, Rooke GA, Wu RS, Bishop MJ. Comparison of the effects of etomidate, propofol, and thiopental on respiratory resistance after tracheal intubation. Anesthesiology. 1996; 84:1307–11. PMid:8669670 DOI:
  10. Zed PJ, Mabasa VH, Slavik RS, Abu-Laban RB. Etomidate for rapid sequence intubation in the emergency department: Is adrenal suppression a concern? Canadian Journal of Emergency Medicine. 2006; 8:347–50. PMid:17338847 DOI:
  11. Lipiner-Friedman D, Sprung CL, Laterre PF, Weiss Y, Goodman SV, Vogeser M, et al. Adrenal function in sepsis: The retrospective Corticus cohort study. Critical Care Medicine. 2007; 35:1012–8. PMid:17334243 DOI:
  12. Lundy JB, Slane ML, Frizzi JD. Acute adrenal insufficiency after a single dose of etomidate. Journal of Intensive Care Medicine. 2007; 22:111–7. PMid:17456730 DOI:
  13. Bae JY, Choi do Y, Woo CH, Kwak IS, Mun SH, Kim KM. The BIS and hemodynamic changes in major burn patients according to a slow infusion of propofol for induction. Korean Journal of Anesthesiology. 2011; 60:161–6. PMid:21490816. PMCid: PMC3071478 DOI:
  14. Ebert TJ, Muzi M, Berens R, Goff D, Kampine JP. Sympathetic responses to induction of anesthesia in humans with propofol or etomidate. Anesthesiology. 1992; 76:725–33. PMid:1575340 DOI:
  15. Ouedraogo N, Marthan R, Roux E. The effects of propofol and etomidate on airway contractility in chronically hypoxic rats. Anesthesia & Analgesia. 2003; 96:1035–41. PMid:12651655 DOI:
  16. Jellish WS, Riche H, Salord F, Ravussin P, Tempelhoff R. Etomidate thiopental based ansthetic induction: Comparisons between different titrated levels of electrophysiologic cortical depression and response to laryngoscopy. Journal of Clinical Anesthesia. 1997; 9:36–41. DOI:
  17. Brohon E, Hans P, Schoofs R, Merciny F. Comparison of 4 anesthesia induction protocols on hemodynamic changes in tracheal intubation. Agressologie. 1993; 34:83–4.